prikaz prve stranice dokumenta Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
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Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
Scientific Reports, 11 (2021), 1; 21514. https://doi.org/10.1038/s41598-021-00928-w
Kukla, Michał; Menżyk, Tomasz; Dembiński, Marcin; Winiarski, Marek; Garlicki, Aleksander; Bociąga-Jasik, Monika; Skonieczna, Magdalena; Hudy, Dorota; Maziarz, Barbara; Kusnierz-Cabala, Beata; Skladany, Lubomir; Grgurević, Ivica; Wójcik-Bugajska, Małgorzata; Grodzicki, Tomasz; Stygar, Dominika; Rogula, Tomasz Više autora...

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Kukla, M., Menżyk, T., Dembiński, M., Winiarski, M., Garlicki, A., Bociąga Jasik, M. ... Rogula, T. (2021). Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes. Scientific Reports, 11. (1). doi: 10.1038/s41598-021-00928-w

Kukla, Michał, et al. "Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes." Scientific Reports, vol. 11, br. 1, 2021. https://doi.org/10.1038/s41598-021-00928-w

Kukla, Michał, Tomasz Menżyk, Marcin Dembiński, Marek Winiarski, Aleksander Garlicki, Monika Bociąga Jasik, Magdalena Skonieczna, et al. "Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes." Scientific Reports 11, br. 1 (2021). https://doi.org/10.1038/s41598-021-00928-w

Kukla, M., et al. (2021) 'Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes', Scientific Reports, 11(1). doi: 10.1038/s41598-021-00928-w

Kukla M, Menżyk T, Dembiński M, Winiarski M, Garlicki A, Bociąga Jasik M, i sur.. Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes. Scientific Reports [Internet]. 02.11.2021. [pristupljeno 20.12.2024.];11(1). doi: 10.1038/s41598-021-00928-w

M. Kukla, et al., "Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes", Scientific Reports, vol. 11, br. 1, Studeni 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:283619. [Citirano: 20.12.2024.]

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Naslov (engleski)Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
AutorMichał Kukla
AutorTomasz Menżyk
AutorMarcin Dembiński
AutorMarek Winiarski
AutorAleksander Garlicki
AutorMonika Bociąga-Jasik
AutorMagdalena Skonieczna
AutorDorota Hudy
AutorBarbara Maziarz
AutorBeata Kusnierz-Cabala
AutorLubomir Skladany
AutorIvica Grgurević
AutorMałgorzata Wójcik-Bugajska
AutorTomasz Grodzicki
AutorDominika Stygar
AutorTomasz Rogula
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 11, br. 1, 21514
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-021-00928-w
URN:NBNurn:nbn:hr:105:283619
Datum objave publikacije2021-11-02
URL dokumentahttps://www.nature.com/articles/s41598-021-00928-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-03-15 08:29:15