prikaz prve stranice dokumenta Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
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Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
Life, 11 (2021), 9; 989. https://doi.org/10.3390/life11090989
Marić, Tihana; Katušić Bojanac, Ana; Matijević, Ana; Ceppi, Marcello; Bruzzone, Marco; Evgeni, Evangelini; Petrovic, Tea; Wójcik, Iwona; Trbojevic-Akmacic, Irena; Lauc, Gordan; Ježek, Davor; Fučić, Aleksandra

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Marić, T., Katušić Bojanac, A., Matijević, A., Ceppi, M., Bruzzone, M., Evgeni, E. ... Fučić, A. (2021). Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men. Life, 11. (9). doi: 10.3390/life11090989

Marić, Tihana, et al. "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men." Life, vol. 11, br. 9, 2021. https://doi.org/10.3390/life11090989

Marić, Tihana, Ana Katušić Bojanac, Ana Matijević, Marcello Ceppi, Marco Bruzzone, Evangelini Evgeni, Tea Petrovic, et al. "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men." Life 11, br. 9 (2021). https://doi.org/10.3390/life11090989

Marić, T., et al. (2021) 'Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men', Life, 11(9). doi: 10.3390/life11090989

Marić T, Katušić Bojanac A, Matijević A, Ceppi M, Bruzzone M, Evgeni E, i sur.. Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men. Life [Internet]. 20.09.2021. [pristupljeno 18.10.2024.];11(9). doi: 10.3390/life11090989

T. Marić, et al., "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men", Life, vol. 11, br. 9, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:076068. [Citirano: 18.10.2024.]

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Naslov (engleski)Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
AutorTihana Marić
AutorAna Katušić Bojanac
AutorAna Matijević
AutorMarcello Ceppi
AutorMarco Bruzzone
AutorEvangelini Evgeni
AutorTea Petrovic
AutorIwona Wójcik
AutorIrena Trbojevic-Akmacic
AutorGordan Lauc
AutorDavor Ježek
AutorAleksandra Fučić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Background: Male infertility is increasingly becoming a health and demographic problem. While it may originate from congenital or acquired diseases, it can also result from environmental exposure. Hence, the complexity of involved molecular mechanisms often requires a multiparametric approach. This study aimed to associate semen parameters with sperm DNA fragmentation, chromatin maturity and seminal plasma protein N-glycosylation. ----- Methods: The study was conducted with 166 participants, 20–55 y old, 82 normozoospermic and 84 with pathological diagnosis. Sperm was analyzed by Halosperm assay and aniline blue staining, while seminal plasma total protein N-glycans were analyzed by ultra-high-performance liquid chromatography. ----- Results: Sperm DNA fragmentation was significantly increased in the pathological group and was inversely correlated with sperm motility and viability. Seminal plasma total protein N-glycans were chromatographically separated in 37 individual peaks. The pattern of seminal plasma N-glycan peaks (SPGP) showed that SPGP14 significantly differs between men with normal and pathological semen parameters (p < 0.001). The multivariate analysis showed that when sperm chromatin maturity increases by 10%, SPGP17 decreases by 14% while SPGP25 increases by 25%. ----- Conclusion: DNA integrity and seminal plasma N-glycans are associated with pathological sperm parameters. Specific N-glycans are also associated with sperm chromatin maturity and have a potential in future fertility research and clinical diagnostics.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 11, br. 9, 989
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life11090989
URN:NBNurn:nbn:hr:105:076068
Datum objave publikacije2021-09-20
URL dokumentahttps://www.mdpi.com/2075-1729/11/9/989
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-21 07:30:35