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Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
Cancer Cell International, 21 (2021), 1; 388. https://doi.org/10.1186/s12935-021-02091-8
Javed, Zeeshan; Khan, Khushbukhat; Herrera-Bravo, Jesús; Naeem, Sajid; Iqbal, Muhammad Javed; Sadia, Haleema; Qadri, Qamar Raza; Raza, Shahid; Irshad, Asma; Akbar, Ali; Reiner, Željko; Al-Harrasi, Ahmed; Al-Rawahi, Ahmed; Satmbekova, Dinara; Butnariu, Monica; Bagiu, Iulia Cristina; Bagiu, Radu Vasile; Sharifi-Rad, Javad Više autora...

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Javed, Z., Khan, K., Herrera Bravo, J., Naeem, S., Iqbal, M. J., Sadia, H. ... Sharifi Rad, J. (2021). Genistein as a regulator of signaling pathways and microRNAs in different types of cancers. Cancer Cell International, 21. (1). doi: 10.1186/s12935-021-02091-8

Javed, Zeeshan, et al. "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers." Cancer Cell International, vol. 21, br. 1, 2021. https://doi.org/10.1186/s12935-021-02091-8

Javed, Zeeshan, Khushbukhat Khan, Jesús Herrera Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, et al. "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers." Cancer Cell International 21, br. 1 (2021). https://doi.org/10.1186/s12935-021-02091-8

Javed, Z., et al. (2021) 'Genistein as a regulator of signaling pathways and microRNAs in different types of cancers', Cancer Cell International, 21(1). doi: 10.1186/s12935-021-02091-8

Javed Z, Khan K, Herrera Bravo J, Naeem S, Iqbal MJ, Sadia H, i sur.. Genistein as a regulator of signaling pathways and microRNAs in different types of cancers. Cancer Cell International [Internet]. 21.07.2021. [pristupljeno 09.05.2024.];21(1). doi: 10.1186/s12935-021-02091-8

Z. Javed, et al., "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers", Cancer Cell International, vol. 21, br. 1, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:385664. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:385664
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Naslov (engleski)Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
AutorZeeshan Javed
AutorKhushbukhat Khan
AutorJesús Herrera-Bravo
AutorSajid Naeem
AutorMuhammad Javed Iqbal
AutorHaleema Sadia
AutorQamar Raza Qadri
AutorShahid Raza
AutorAsma Irshad
AutorAli Akbar
AutorŽeljko Reiner
AutorAhmed Al-Harrasi
AutorAhmed Al-Rawahi
AutorDinara Satmbekova
AutorMonica Butnariu
AutorIulia Cristina Bagiu
AutorRadu Vasile Bagiu
AutorJavad Sharifi-Rad
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancer Cell International
Brojčani podacivol. 21, br. 1, 388
e-ISSN1475-2867
DOIhttps://doi.org/10.1186/s12935-021-02091-8
URN:NBNurn:nbn:hr:105:385664
Datum objave publikacije2021-07-21
URL dokumentahttps://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02091-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-06 07:50:45