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Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance
Progress in Orthodontics, 22 (2021), 1; 19. https://doi.org/10.1186/s40510-021-00364-6
Grgurević, Lovorka; Novak, Ruđer; Salai, Grgur; Trkulja, Vladimir; Ferhatovicć Hamzić, Lejla; Zgombić Popović, Vojka; Božić, Darko

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Grgurević, L., Novak, R., Salai, G., Trkulja, V., Ferhatovicć Hamzić, L., Zgombić Popović, V. i Božić, D. (2021). Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance. Progress in Orthodontics, 22. (1). doi: 10.1186/s40510-021-00364-6

Grgurević, Lovorka, et al. "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance." Progress in Orthodontics, vol. 22, br. 1, 2021. https://doi.org/10.1186/s40510-021-00364-6

Grgurević, Lovorka, Ruđer Novak, Grgur Salai, Vladimir Trkulja, Lejla Ferhatovicć Hamzić, Vojka Zgombić Popović i Darko Božić. "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance." Progress in Orthodontics 22, br. 1 (2021). https://doi.org/10.1186/s40510-021-00364-6

Grgurević, L., et al. (2021) 'Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance', Progress in Orthodontics, 22(1). doi: 10.1186/s40510-021-00364-6

Grgurević L, Novak R, Salai G, Trkulja V, Ferhatovicć Hamzić L, Zgombić Popović V, i sur.. Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance. Progress in Orthodontics [Internet]. 12.07.2021. [pristupljeno 07.11.2024.];22(1). doi: 10.1186/s40510-021-00364-6

L. Grgurević, et al., "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance", Progress in Orthodontics, vol. 22, br. 1, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:004196. [Citirano: 07.11.2024.]

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Podaci o radu
Naslov (engleski)Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance
AutorLovorka Grgurević
AutorRuđer Novak
AutorGrgur Salai
AutorVladimir Trkulja
AutorLejla Ferhatovicć Hamzić
AutorVojka Zgombić Popović
AutorDarko Božić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Background: This study was conducted in order to explore the effects of orthodontic tooth movement (OTM) on the changes of salivary proteome. This prospective observational pilot study recruited 12 healthy teenage boys with malocclusion treated with a fixed orthodontic appliance and 6 appropriate control participants. Saliva samples were collected a day before and at 0, 2, 7, and 30 days after initialization of treatment, corresponding to the initial, lag, and post-lag phases of OTM. Pooled samples were analyzed by liquid chromatography-mass spectrometry, ELISA, and Western blotting. To date, there is no published data on the presence of BMP molecules or their antagonists in the saliva or in the gingival cervical fluid related to orthodontic conditions. ----- Results: A total of 198 identified saliva proteins were classified based on their functional characteristics. Proteins involved in bone remodeling were observed exclusively 30 days post appliance placement, including bone morphogenetic protein 4 (BMP4), a BMP antagonist BMP-binding endothelial regulator, insulin-like growth factor-binding protein 3, cytoskeleton-associated protein 4, and fibroblast growth factor 5. Based on the analysis of protein interactions, BMP4 was found to have a central position in this OTM-related protein network. ----- Conclusions: The placement of a fixed orthodontic appliance induced occurrence of proteins involved in bone remodeling in the saliva at a time corresponding to the post-lag period of OTM. Limitations of this study include a relatively small sample size, limited time of monitoring patients, and the lack of interindividual variability assessment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProgress in Orthodontics
Brojčani podacivol. 22, br. 1, 19
e-ISSN2196-1042
DOIhttps://doi.org/10.1186/s40510-021-00364-6
URN:NBNurn:nbn:hr:105:004196
Datum objave publikacije2021-07-12
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Kratica: CERRM
Voditelj: Slobodan Vukičević
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://progressinorthodontics.springeropen.com/articles/10.1186/s40510-021-00364-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-09 07:39:37