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The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study
Arthritis & Rheumatology, 75 (2023), 4; 499-506. https://doi.org/10.1002/art.42411
Batu, Ezgi D.; Sener, Seher; Ozomay Baykal, Gulcan; Arslanoglu Aydin, Elif; Özdel, Semanur; Gagro, Alenka; Esen, Esra; Heshin‐Bekenstein, Merav; Akpınar Tekgöz, Nilüfer; Demirkan, Fatma G.; Ozturk, Kubra; Vougiouka, Olga; Sonmez, H. Emine; Maggio, Maria Cristina; Kaya Akca, Ummusen; Jelušić, Marija; Pac Kısaarslan, Aysenur; Acar, Banu; Aktay Ayaz, Nuray; Sözeri, Betül; Özen, Seza Više autora...

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Batu, E. D., Sener, S., Ozomay Baykal, G., Arslanoglu Aydin, E., Özdel, S., Gagro, A. ... Özen, S. (2023). The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study. Arthritis & Rheumatology, 75. (4), 499-506. doi: 10.1002/art.42411

Batu, Ezgi D., et al. "The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study." Arthritis & Rheumatology, vol. 75, br. 4, 2023, str. 499-506. https://doi.org/10.1002/art.42411

Batu, Ezgi D., Seher Sener, Gulcan Ozomay Baykal, Elif Arslanoglu Aydin, Semanur Özdel, Alenka Gagro, Esra Esen, et al. "The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study." Arthritis & Rheumatology 75, br. 4 (2023): 499-506. https://doi.org/10.1002/art.42411

Batu, E. D., et al. (2023) 'The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study', Arthritis & Rheumatology, 75(4), str. 499-506. doi: 10.1002/art.42411

Batu ED, Sener S, Ozomay Baykal G, Arslanoglu Aydin E, Özdel S, Gagro A, i sur.. The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study. Arthritis & Rheumatology [Internet]. 04.2023. [pristupljeno 08.11.2024.];75(4):499-506. doi: 10.1002/art.42411

E. D. Batu, et al., "The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study", Arthritis & Rheumatology, vol. 75, br. 4, str. 499-506, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:574742. [Citirano: 08.11.2024.]

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Naslov (engleski)The Characteristics of Patients With COVID-19-Associated Pediatric Vasculitis: An International, Multicenter Study
AutorEzgi D. Batu
AutorSeher Sener
AutorGulcan Ozomay Baykal
AutorElif Arslanoglu Aydin
AutorSemanur Özdel
AutorAlenka Gagro
AutorEsra Esen
AutorMerav Heshin‐Bekenstein
AutorNilüfer Akpınar Tekgöz
AutorFatma G. Demirkan
AutorKubra Ozturk
AutorOlga Vougiouka
AutorH. Emine Sonmez
AutorMaria Cristina Maggio
AutorUmmusen Kaya Akca
AutorMarija Jelušić
AutorAysenur Pac Kısaarslan
AutorBanu Acar
AutorNuray Aktay Ayaz
AutorBetül Sözeri
AutorSeza Özen
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Objective: COVID-19-associated pediatric vasculitis, other than Kawasaki disease (KD)-like vasculitis in multisystem inflammatory syndrome in children (MIS-C), is very rare. This study sought to analyze the characteristics, treatment, and outcomes in patients with COVID-19-associated pediatric vasculitis (excluding KD-like vasculitis in MIS-C). Methods: The inclusion criteria were as follows: 1) age <18 years at vasculitis onset; 2) evidence of vasculitis; 3) evidence of SARS-CoV-2 exposure; and 4) ≤3 months between SARS-CoV-2 exposure and vasculitis onset. Patients with MIS-C were excluded. The features of the subset of patients in our cohort who had COVID-19-associated pediatric IgA vasculitis/Henoch Schönlein purpura (IgAV/HSP) were compared against a pre-pandemic cohort of pediatric IgAV/HSP patients. Results: Forty-one patients (median age 8.3 years; male to female ratio 1.3) were included from 14 centers and 6 countries. The most frequent vasculitis subtype was IgAV/HSP (n = 30). The median duration between SARS-CoV-2 exposure and vasculitis onset was 13 days. Involvement of the skin (92.7%) and of the gastrointestinal system (61%) were the most common manifestations of vasculitis. Most patients (68.3%) received glucocorticoids, and 14.6% also received additional immunosuppressive drugs. Remission was achieved in all patients. All of the patients with IgAV/HSP in our cohort had skin manifestations, while 18 (60%) had gastrointestinal involvement and 13 (43.3%) had renal involvement. When we compared the features of this subset of 30 patients to those of a pre-pandemic pediatric IgAV/HSP cohort (n = 159), the clinical characteristics of fever and renal involvement were more common in our COVID-19-associated pediatric IgAV/HSP cohort (fever, 30% versus 5%, respectively [P < 0.001]; renal involvement, 43.3% versus 17.6%, respectively [P = 0.002]). Recovery without treatment and complete recovery were each less frequent among our COVID-19-associated pediatric IgAV/HSP patients compared to the pre-pandemic pediatric IgAV/HSP cohort (recovery without treatment, 10% versus 39%, respectively [P = 0.002]; complete recovery, 86.7% versus 99.4%, respectively [P = 0.002]). Conclusion: This is the largest cohort of children with COVID-19-associated vasculitis (excluding MIS-C) studied to date. Our findings suggest that children with COVID-19-associated IgAV/HSP experience a more severe disease course compared to pediatric IgAV/HSP patients before the pandemic.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArthritis & Rheumatology
Brojčani podacivol. 75, br. 4, str. 499-506
p-ISSN2326-5191
e-ISSN2326-5205
DOIhttps://doi.org/10.1002/art.42411
URN:NBNurn:nbn:hr:105:574742
Datum objave publikacije2023-04
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/art.42411
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-07-11 11:24:14