Transcriptional Profile of the Developing Subthalamic Nucleus

Znanstveni rad - Pregledni rad

• Autor: Ema Bokulić
• Autor: Tila Medenica
• Autor: Goran Sedmak
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti; Neuroznanost

Sažetak (engleski)

The subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson’s disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations are still being debated. The classical model of forebrain development attributed the origin of STN within the diencephalon. Recent studies of gene expression patterns exposed shortcomings of the classical model. To accommodate these findings, the prosomeric model was developed. In this concept, STN develops within the hypothalamic primordium, which is no longer a part of the diencephalic primordium. This concept is further supported by the expression patterns of many transcription factors. It is interesting to note that many transcription factors involved in the development of the STN are also involved in the pathogenesis of neurodevelopmental disorders. Thus, the study of neurodevelopmental disorders could provide us with valuable information on the roles of these transcription factors in the development and maintenance of STN phenotype. In this review, we summarize historical theories about the developmental origin of the STN and interpret the gene expression data within the prosomeric conceptual framework. Finally, we discuss the importance of neurodevelopmental disorders for the development of the STN and its potential role in the pathophysiology of neurodevelopmental disorders.

• Ključne riječi (engleski): Basal Ganglia / physiology; Humans; Neurons / physiology; Parkinson Disease / metabolism; Subthalamic Nucleus / physiology; Transcription Factors / genetics; Transcription Factors / metabolism
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: eNeuro
• Brojčani podaci: vol. 9, br. 5, ENEURO.0193-22.2022
• p-ISSN: 2373-2822
• DOI: https://doi.org/10.1523/ENEURO.0193-22.2022
• URN:NBN: urn:nbn:hr:105:177571
• Datum objave publikacije: 2022-10-18
• URL dokumenta: https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0193-22.2022
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2023-08-22 07:40:37