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Upper cortical layer–driven network impairment in schizophrenia
Science Advances, 8 (2022), 41; eabn8367. https://doi.org/10.1126/sciadv.abn8367
Batiuk, Mykhailo Y.; Tyler, Teadora; Dragicevic, Katarina; Mei, Shenglin; Rydbirk, Rasmus; Petukhov, Viktor; Deviatiiarov, Ruslan; Sedmak, Dora; Frank, Erzsebet; Feher, Virginia; Habek, Nikola; Hu, Qiwen; Igolkina, Anna; Roszik, Lilla; Pfisterer, Ulrich; Garcia-Gonzalez, Diego; Petanjek, Zdravko; Adorjan, Istvan; Kharchenko, Peter V.; Khodosevich, Konstantin Više autora...

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Batiuk, M. Y., Tyler, T., Dragicevic, K., Mei, S., Rydbirk, R., Petukhov, V. ... Khodosevich, K. (2022). Upper cortical layer–driven network impairment in schizophrenia. Science Advances, 8. (41). doi: 10.1126/sciadv.abn8367

Batiuk, Mykhailo Y., et al. "Upper cortical layer–driven network impairment in schizophrenia." Science Advances, vol. 8, br. 41, 2022. https://doi.org/10.1126/sciadv.abn8367

Batiuk, Mykhailo Y., Teadora Tyler, Katarina Dragicevic, Shenglin Mei, Rasmus Rydbirk, Viktor Petukhov, Ruslan Deviatiiarov, et al. "Upper cortical layer–driven network impairment in schizophrenia." Science Advances 8, br. 41 (2022). https://doi.org/10.1126/sciadv.abn8367

Batiuk, M. Y., et al. (2022) 'Upper cortical layer–driven network impairment in schizophrenia', Science Advances, 8(41). doi: 10.1126/sciadv.abn8367

Batiuk MY, Tyler T, Dragicevic K, Mei S, Rydbirk R, Petukhov V, i sur.. Upper cortical layer–driven network impairment in schizophrenia. Science Advances [Internet]. 14.10.2022. [pristupljeno 30.11.2024.];8(41). doi: 10.1126/sciadv.abn8367

M. Y. Batiuk, et al., "Upper cortical layer–driven network impairment in schizophrenia", Science Advances, vol. 8, br. 41, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:697862. [Citirano: 30.11.2024.]

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Podaci o radu
Naslov (engleski)Upper cortical layer–driven network impairment in schizophrenia
AutorMykhailo Y. Batiuk
AutorTeadora Tyler
AutorKatarina Dragicevic
AutorShenglin Mei
AutorRasmus Rydbirk
AutorViktor Petukhov
AutorRuslan Deviatiiarov
AutorDora Sedmak
AutorErzsebet Frank
AutorVirginia Feher
AutorNikola Habek
AutorQiwen Hu
AutorAnna Igolkina
AutorLilla Roszik
AutorUlrich Pfisterer
AutorDiego Garcia-Gonzalez
AutorZdravko Petanjek
AutorIstvan Adorjan
AutorPeter V. Kharchenko
AutorKonstantin Khodosevich
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Schizophrenia is one of the most widespread and complex mental disorders. To characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) of >220,000 neurons from the dorsolateral prefrontal cortex of patients with schizophrenia and matched controls. In addition, >115,000 neurons were analyzed topographically by immunohistochemistry. Compositional analysis of snRNA-seq data revealed a reduction in abundance of GABAergic neurons and a concomitant increase in principal neurons, most pronounced for upper cortical layer subtypes, which was substantiated by histological analysis. Many neuronal subtypes showed extensive transcriptomic changes, the most marked in upper-layer GABAergic neurons, including down-regulation in energy metabolism and up-regulation in neurotransmission. Transcription factor network analysis demonstrated a developmental origin of transcriptomic changes. Last, Visium spatial transcriptomics further corroborated upper-layer neuron vulnerability in schizophrenia. Overall, our results point toward general network impairment within upper cortical layers as a core substrate associated with schizophrenia symptomatology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScience Advances
Brojčani podacivol. 8, br. 41, eabn8367
e-ISSN2375-2548
DOIhttps://doi.org/10.1126/sciadv.abn8367
URN:NBNurn:nbn:hr:105:697862
Datum objave publikacije2022-10-14
URL dokumentahttps://www.science.org/doi/10.1126/sciadv.abn8367
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-08-23 08:32:14