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Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
Pharmaceutics, 15 (2023), 6; 1660. https://doi.org/10.3390/pharmaceutics15061660
Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Safundžić Kučuk, Maša; Trenkel, Marie; Scherließ, Regina; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita

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Perkušić, M., Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Pepić, I. ... Hafner, A. (2023). Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile. Pharmaceutics, 15. (6). doi: 10.3390/pharmaceutics15061660

Perkušić, Mirna, et al. "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile." Pharmaceutics, vol. 15, br. 6, 2023. https://doi.org/10.3390/pharmaceutics15061660

Perkušić, Mirna, Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Ivan Pepić, Jasmina Lovrić, et al. "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile." Pharmaceutics 15, br. 6 (2023). https://doi.org/10.3390/pharmaceutics15061660

Perkušić, M., et al. (2023) 'Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile', Pharmaceutics, 15(6). doi: 10.3390/pharmaceutics15061660

Perkušić M, Nižić Nodilo L, Ugrina I, Špoljarić D, Jakobušić Brala C, Pepić I, i sur.. Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile. Pharmaceutics [Internet]. 05.06.2023. [pristupljeno 11.04.2024.];15(6). doi: 10.3390/pharmaceutics15061660

M. Perkušić, et al., "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile", Pharmaceutics, vol. 15, br. 6, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:502735. [Citirano: 11.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:502735
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Naslov (engleski)Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
AutorMirna Perkušić
AutorLaura Nižić Nodilo
AutorIvo Ugrina
AutorDrago Špoljarić
AutorCvijeta Jakobušić Brala
AutorIvan Pepić
AutorJasmina Lovrić
AutorMaša Safundžić Kučuk
AutorMarie Trenkel
AutorRegina Scherließ
AutorDijana Zadravec
AutorLivije Kalogjera
AutorAnita Hafner
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA OTORINOLARINGOLOGIJU I KIRURGIJU GLAVE I VRATA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Sažetak (engleski)
Donepezil nasal delivery strategies are being continuously investigated for advancing therapy in Alzheimer’s disease. The aim of this study was to develop a chitosan-based, donepezil-loaded thermogelling formulation tailored to meet all the requirements for efficient nose-to-brain delivery. A statistical design of the experiments was implemented for the optimisation of the formulation and/or administration parameters, with regard to formulation viscosity, gelling and spray properties, as well as its targeted nasal deposition within the 3D-printed nasal cavity model. The optimised formulation was further characterised in terms of stability, in vitro release, in vitro biocompatibility and permeability (using Calu-3 cells), ex vivo mucoadhesion (using porcine nasal mucosa), and in vivo irritability (using slug mucosal irritation assay). The applied research design resulted in the development of a sprayable donepezil delivery platform characterised by instant gelation at 34 °C and olfactory deposition reaching a remarkably high 71.8% of the applied dose. The optimised formulation showed prolonged drug release (t1/2 about 90 min), mucoadhesive behaviour, and reversible permeation enhancement, with a 20-fold increase in adhesion and a 1.5-fold increase in the apparent permeability coefficient in relation to the corresponding donepezil solution. The slug mucosal irritation assay demonstrated an acceptable irritability profile, indicating its potential for safe nasal delivery. It can be concluded that the developed thermogelling formulation showed great promise as an efficient donepezil brain-targeted delivery system. Furthermore, the formulation is worth investigating in vivo for final feasibility confirmation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceutics
Brojčani podacivol. 15, br. 6, 1660
e-ISSN1999-4923
DOIhttps://doi.org/10.3390/pharmaceutics15061660
URN:NBNurn:nbn:hr:105:502735
Datum objave publikacije2023-06-05
ProjektŠifra: UIP-2017-05-4592
Naziv (hrvatski): Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini
Kratica: OptiNasalSpray
Voditelj: Anita Hafner
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://www.mdpi.com/1999-4923/15/6/1660
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-09-18 08:39:39