prikaz prve stranice dokumenta From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
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From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
Pharmaceuticals, 16 (2023), 12; 1699. https://doi.org/10.3390/ph16121699
Sikirić, Predrag; Boban Blagaić, Alenka; Krezic, Ivan; Žižek, Helena; Kalogjera, Luka; Smoday, Ivan Maria; Vuković, Vlasta; Oroz, Katarina; Chiddenton, Helen Marie; Buric, Sara; Antunović, Marko; Gojković, Slaven; Štrbe, Sanja; Skočić, Milena; Sikirić, Sunčana; Milavić, Marija; Beketić Orešković, Lidija; Kokot, Antonio; Koprivanac, Antun; Dobrić, Ivan; Sever, Marko; Starešinić, Mario; Batelja Vuletić, Lovorka; Škrtić, Anita; Seiwerth, Sven Više autora...

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Sikirić, P., Boban Blagaić, A., Krezic, I., Žižek, H., Kalogjera, L., Smoday, I. M. ... Seiwerth, S. (2023). From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities. Pharmaceuticals, 16. (12). doi: 10.3390/ph16121699

Sikirić, Predrag, et al. "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities." Pharmaceuticals, vol. 16, br. 12, 2023. https://doi.org/10.3390/ph16121699

Sikirić, Predrag, Alenka Boban Blagaić, Ivan Krezic, Helena Žižek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vuković, et al. "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities." Pharmaceuticals 16, br. 12 (2023). https://doi.org/10.3390/ph16121699

Sikirić, P., et al. (2023) 'From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities', Pharmaceuticals, 16(12). doi: 10.3390/ph16121699

Sikirić P, Boban Blagaić A, Krezic I, Žižek H, Kalogjera L, Smoday IM, i sur.. From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities. Pharmaceuticals [Internet]. 07.12.2023. [pristupljeno 18.04.2024.];16(12). doi: 10.3390/ph16121699

P. Sikirić, et al., "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities", Pharmaceuticals, vol. 16, br. 12, Prosinac 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:485424. [Citirano: 18.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:485424
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Podaci o radu
Naslov (engleski)From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
AutorPredrag Sikirić
AutorAlenka Boban Blagaić
AutorIvan Krezic
AutorHelena Žižek
AutorLuka Kalogjera
AutorIvan Maria Smoday
AutorVlasta Vuković
AutorKatarina Oroz
AutorHelen Marie Chiddenton
AutorSara Buric
AutorMarko Antunović
AutorSlaven Gojković
AutorSanja Štrbe
MBZ: 319335
AutorMilena Skočić
AutorSunčana Sikirić
AutorMarija Milavić
AutorLidija Beketić Orešković
AutorAntonio Kokot
AutorAntun Koprivanac
AutorIvan Dobrić
AutorMarko Sever
AutorMario Starešinić
AutorLovorka Batelja Vuletić
AutorAnita Škrtić
AutorSven Seiwerth
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients. Szabo’s cysteamine duodenal ulcer as the dopamine duodenal healing and cysteamine as a dopamine antagonist signifies the dopamine agonists anti-ulcer effect and dopamine antagonists ulcerogenic effect. From these viewpoints, we focused on dopamine and gastric ulcer healing. We mentioned antecedent studies on the dopamine presence in the stomach and gastric juice. Then we reviewed, in the timeline, therapy significance arising from the anti-ulcer potency of the various dopamine agonists, which is highly prevailing over the quite persistent beneficial evidence arising from the various dopamine antagonists. Meanwhile, the beneficial effects of several peptides (i.e., amylin, cholecystokinin, leptin, and stable gastric pentadecapeptide BPC 157, suggested as an acting mediator of the dopamine brain-gut axis) were included in the dopamine gastric ulcer story. We attempt to resolve dopamine agonists/antagonists issue with the dopamine significance in the stress (cysteamine as a prototype of the duodenal stress ulcer), and cytoprotection (cysteamine in small dose as a prototype of the cytoprotective agents; cysteamine duodenal ulcer in gastrectomized rats). Thereby, along with dopamine agonists’ beneficial effects, in special circumstances, dopamine antagonists having their own ulcerogenic effect may act as “mild stress (or)” or “small irritant” counteracting subsequent strong alcohol or stress procedure-induced severe lesions in this particular tissue. Finally, in the conclusion, as a new improvement in further therapy, we emphasized the advantages of the dopamine agents’ application in lower gastrointestinal tract therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPharmaceuticals
Brojčani podacivol. 16, br. 12, 1699
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16121699
URN:NBNurn:nbn:hr:105:485424
Datum objave publikacije2023-12-07
URL dokumentahttps://www.mdpi.com/1424-8247/16/12/1699
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-03-01 11:19:19