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In vivo fate mapping identifies mesenchymal progenitor cells
Stem Cells, 30 (2012), 2; 187-196. https://doi.org/10.1002/stem.780
Grčević, Danka; Pejda, Slavica; Matthews, Brya G.; Repić, Dario; Wang, Liping; Li, Haitao; Kronenberg, Mark S.; Jiang, Xi; Maye, Peter; Adams, Douglas J.; Rowe, David W.; Aguila, Hector L.; Kalajzić, Ivo

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Grčević, D., Pejda, S., Matthews, B. G., Repić, D., Wang, L., Li, H. ... Kalajzić, I. (2012). In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells, 30. (2), 187-196. doi: 10.1002/stem.780

Grčević, Danka, et al. "In vivo fate mapping identifies mesenchymal progenitor cells." Stem Cells, vol. 30, br. 2, 2012, str. 187-196. https://doi.org/10.1002/stem.780

Grčević, Danka, Slavica Pejda, Brya G. Matthews, Dario Repić, Liping Wang, Haitao Li, Mark S. Kronenberg, et al. "In vivo fate mapping identifies mesenchymal progenitor cells." Stem Cells 30, br. 2 (2012): 187-196. https://doi.org/10.1002/stem.780

Grčević, D., et al. (2012) 'In vivo fate mapping identifies mesenchymal progenitor cells', Stem Cells, 30(2), str. 187-196. doi: 10.1002/stem.780

Grčević D, Pejda S, Matthews BG, Repić D, Wang L, Li H, i sur.. In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells [Internet]. 02.2012. [pristupljeno 23.11.2024.];30(2):187-196. doi: 10.1002/stem.780

D. Grčević, et al., "In vivo fate mapping identifies mesenchymal progenitor cells", Stem Cells, vol. 30, br. 2, str. 187-196, Veljača 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:216677. [Citirano: 23.11.2024.]

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Naslov (engleski)In vivo fate mapping identifies mesenchymal progenitor cells
AutorDanka Grčević
AutorSlavica Pejda
AutorBrya G. Matthews
AutorDario Repić
AutorLiping Wang
AutorHaitao Li
AutorMark S. Kronenberg
AutorXi Jiang
AutorPeter Maye
AutorDouglas J. Adams
AutorDavid W. Rowe
AutorHector L. Aguila
AutorIvo Kalajzić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Adult mesenchymal progenitor cells have enormous potential for use in regenerative medicine. However, the true identity of the progenitors in vivo and their progeny has not been precisely defined. We hypothesize that cells expressing a smooth muscle α-actin promoter (αSMA)-directed Cre transgene represent mesenchymal progenitors of adult bone tissue. By combining complementary colors in combination with transgenes activating at mature stages of the lineage, we characterized the phenotype and confirmed the ability of isolated αSMA(+) cells to progress from a progenitor to fully mature state. In vivo lineage tracing experiments using a new bone formation model confirmed the osteogenic phenotype of αSMA(+) cells. In vitro analysis of the in vivo-labeled SMA9(+) cells supported their differentiation potential into mesenchymal lineages. Using a fracture-healing model, αSMA9(+) cells served as a pool of fibrocartilage and skeletal progenitors. Confirmation of the transition of αSMA9(+) progenitor cells to mature osteoblasts during fracture healing was assessed by activation of bone-specific Col2.3emd transgene. Our findings provide a novel in vivo identification of defined population of mesenchymal progenitor cells with active role in bone remodeling and regeneration.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaStem Cells
Brojčani podacivol. 30, br. 2, str. 187-196
p-ISSN1066-5099
DOIhttps://doi.org/10.1002/stem.780
URN:NBNurn:nbn:hr:105:216677
Datum objave publikacije2012-02
URL dokumentahttps://doi.org/10.1002/stem.780
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:29:35