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Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels
Croatian Medical Journal, 47 (2006), 4; 649-655. urn:nbn:hr:105:954681
Polašek, Ozren; Kolčić, Ivana; Smoljanović, Ankica; Stojanović, Dražen; Grgić, Matijana; Ebling, Barbara; Klarić, Maja; Milas, Josip; Puntarić, Dinko

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Polašek, O., Kolčić, I., Smoljanović, A., Stojanović, D., Grgić, M., Ebling, B. ... Puntarić, D. (2006). Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels. Croatian Medical Journal, 47. (4), 649-655. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:954681

Polašek, Ozren, et al. "Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels." Croatian Medical Journal, vol. 47, br. 4, 2006, str. 649-655. https://urn.nsk.hr/urn:nbn:hr:105:954681

Polašek, Ozren, Ivana Kolčić, Ankica Smoljanović, Dražen Stojanović, Matijana Grgić, Barbara Ebling, Maja Klarić, Josip Milas i Dinko Puntarić. "Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels." Croatian Medical Journal 47, br. 4 (2006): 649-655. https://urn.nsk.hr/urn:nbn:hr:105:954681

Polašek, O., et al. (2006) 'Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels', Croatian Medical Journal, 47(4), str. 649-655. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:954681 (Datum pristupa: 19.12.2024.)

Polašek O, Kolčić I, Smoljanović A, Stojanović D, Grgić M, Ebling B, i sur.. Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels. Croatian Medical Journal [Internet]. 08.2006. [pristupljeno 19.12.2024.];47(4):649-655. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:954681

O. Polašek, et al., "Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels", Croatian Medical Journal, vol. 47, br. 4, str. 649-655, Kolovoz 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:954681. [Citirano: 19.12.2024.]

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Naslov (engleski)Demonstrating reduced environmental and genetic diversity in human isolates by analysis of blood lipid levels
AutorOzren Polašek
AutorIvana Kolčić
AutorAnkica Smoljanović
AutorDražen Stojanović
AutorMatijana Grgić
AutorBarbara Ebling
AutorMaja Klarić
AutorJosip Milas
AutorDinko Puntarić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
AIM: To test the hypothesis that phenotypic diversity in isolated human populations is decreased in comparison with general outbred population because of reduced genetic and environmental diversity. To demonstrate this in populations for which reduced genetic and environmental diversity had already been established, by studying the amount of variation in plasma lipid levels. ----- METHODS: Fasting plasma lipid levels (cholesterol, triglycerides, low density lipoprotein [LDL], and high density lipoprotein [HDL]) were measured in randomly selected 300 inhabitants from 2 isolated human populations, the island of Rab and the neighboring islands of Vis and Lastovo, Croatia. The populations were chosen based on previous analyses of genetic diversity and lifestyle patterns, which were shown to be both less diverse and more uniform than the general Croatian population. We studied whether the 25'-75' and 5'-95' interpercentile ranges in observed values were consistently smaller in 2 samples of 300 examinees from isolated populations in comparison with nearly 6000 examinees from an earlier study who were demographically targeted to represent the larger Croatian population. ----- RESULTS: General population had much wider range of observed values of triglycerides and HDL than both isolated populations. However, both isolated populations exhibited greater extent of variation in the levels of LDL, while the ranges of cholesterol values were similar. ----- CONCLUSION: Although reduced genetic and environmental diversity in isolated human populations should necessarily reduce the variance in observed phenotypic values, it appears that specific population genetic processes in isolated populations could be acting to maintain the variation. Departure from the Hardy-Weinberg equilibrium due to consanguinity, sub-structuring and differentiation within the isolates, and increased rate of new mutations could theoretically explain this paradox.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 47, br. 4, str. 649-655
p-ISSN0353-9504
URN:NBNurn:nbn:hr:105:954681
Datum objave publikacije2006-08
URL dokumentahttp://www.cmj.hr/2006/47/4/16909463.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:31:33