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Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
Antimicrobial Agents and Chemotherapy, 59 (2015), 6; 3084-3089. https://doi.org/10.1128/AAC.05016-14
Erdem, Hakan; Cag, Yasemin; Ozturk-Engin, Derya; Defres, Sylviane; Kaya, Selcuk; Larsen, Lykke; Poljak, Mario; Baršić, Bruno; Argemi, Xavier; Sørensen, Signe Maj; Bohr, Anne Lisbeth; Tattevin, Pierre; Gunst, Jesper Damsgaard; Baštáková, Lenka; Jereb, Matjaž; Johansen, Isik Somuncu; Karabay, Oguz; Pekok, Abdullah Umut; Sipahi, Oguz Resat; Chehri, Mahtab; Beraud, Guillaume; Shehata, Ghaydaa; Del Vecchio, Rosa Fontana; Maresca, Mauro; Karsen, Hasan; Sengoz, Gonul; Sunbul, Mustafa; Yilmaz, Gulden; Yilmaz, Hava; Sharif-Yakan, Ahmad; Kanj, Souha Shararah; Parlak, Emine; Pehlivanoglu, Filiz; Korkmaz, Fatime; Komur, Suheyla; Kose, Sukran; Ulug, Mehmet; Bolukcu, Sibel; Coskuner, Seher Ayten; Ince, Nevin; Akkoyunlu, Yasemin; Halac, Gulistan; Sahin-Horasan, Elif; Tireli, Hulya; Kilicoglu, Gamze; Al-Mahdawi, Akram; Nemli, Salih Atakan; Inan, Asuman; Senbayrak, Seniha; Stahl, Jean Paul; Vahaboglu, Haluk Više autora...

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Erdem, H., Cag, Y., Ozturk Engin, D., Defres, S., Kaya, S., Larsen, L. ... Vahaboglu, H. (2015). Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy, 59. (6), 3084-3089. doi: 10.1128/AAC.05016-14

Erdem, Hakan, et al. "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis." Antimicrobial Agents and Chemotherapy, vol. 59, br. 6, 2015, str. 3084-3089. https://doi.org/10.1128/AAC.05016-14

Erdem, Hakan, Yasemin Cag, Derya Ozturk Engin, Sylviane Defres, Selcuk Kaya, Lykke Larsen, Mario Poljak, et al. "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis." Antimicrobial Agents and Chemotherapy 59, br. 6 (2015): 3084-3089. https://doi.org/10.1128/AAC.05016-14

Erdem, H., et al. (2015) 'Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis', Antimicrobial Agents and Chemotherapy, 59(6), str. 3084-3089. doi: 10.1128/AAC.05016-14

Erdem H, Cag Y, Ozturk Engin D, Defres S, Kaya S, Larsen L, i sur.. Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy [Internet]. 2015. [pristupljeno 20.04.2024.];59(6):3084-3089. doi: 10.1128/AAC.05016-14

H. Erdem, et al., "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis", Antimicrobial Agents and Chemotherapy, vol. 59, br. 6, str. 3084-3089, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:370387. [Citirano: 20.04.2024.]

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Podaci o radu
Naslov (engleski)Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
AutorHakan Erdem
AutorYasemin Cag
AutorDerya Ozturk-Engin
AutorSylviane Defres
AutorSelcuk Kaya
AutorLykke Larsen
AutorMario Poljak
AutorBruno Baršić
AutorXavier Argemi
AutorSigne Maj Sørensen
AutorAnne Lisbeth Bohr
AutorPierre Tattevin
AutorJesper Damsgaard Gunst
AutorLenka Baštáková
AutorMatjaž Jereb
AutorIsik Somuncu Johansen
AutorOguz Karabay
AutorAbdullah Umut Pekok
AutorOguz Resat Sipahi
AutorMahtab Chehri
AutorGuillaume Beraud
AutorGhaydaa Shehata
AutorRosa Fontana Del Vecchio
AutorMauro Maresca
AutorHasan Karsen
AutorGonul Sengoz
AutorMustafa Sunbul
AutorGulden Yilmaz
AutorHava Yilmaz
AutorAhmad Sharif-Yakan
AutorSouha Shararah Kanj
AutorEmine Parlak
AutorFiliz Pehlivanoglu
AutorFatime Korkmaz
AutorSuheyla Komur
AutorSukran Kose
AutorMehmet Ulug
AutorSibel Bolukcu
AutorSeher Ayten Coskuner
AutorNevin Ince
AutorYasemin Akkoyunlu
AutorGulistan Halac
AutorElif Sahin-Horasan
AutorHulya Tireli
AutorGamze Kilicoglu
AutorAkram Al-Mahdawi
AutorSalih Atakan Nemli
AutorAsuman Inan
AutorSeniha Senbayrak
AutorJean Paul Stahl
AutorHaluk Vahaboglu
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAntimicrobial Agents and Chemotherapy
Brojčani podacivol. 59, br. 6, str. 3084-3089
p-ISSN0066-4804
DOIhttps://doi.org/10.1128/AAC.05016-14
URN:NBNurn:nbn:hr:105:370387
Datum objave publikacije2015
URL dokumentahttps://doi.org/10.1128/AAC.05016-14
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:10:41