prikaz prve stranice dokumenta Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia
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Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia
Wiener Klinische Wochenschrift, 128 (2016), 11-12; 404-413. https://doi.org/10.1007/s00508-016-1005-x
Bedenić, Branka; Firis, Nataša; Elveđi-Gašparović, Vesna; Krilanović, Marija; Matanović, Krešimir; Štimac, Iva; Luxner, Josefa; Vraneš, Jasmina; Meštrović, Tomislav; Zarfel, Gernot; Grisold, Andrea

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Bedenić, B., Firis, N., Elveđi Gašparović, V., Krilanović, M., Matanović, K., Štimac, I. ... Grisold, A. (2016). Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia. Wiener Klinische Wochenschrift, 128. (11-12), 404-413. doi: 10.1007/s00508-016-1005-x

Bedenić, Branka, et al. "Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia." Wiener Klinische Wochenschrift, vol. 128, br. 11-12, 2016, str. 404-413. https://doi.org/10.1007/s00508-016-1005-x

Bedenić, Branka, Nataša Firis, Vesna Elveđi Gašparović, Marija Krilanović, Krešimir Matanović, Iva Štimac, Josefa Luxner, et al. "Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia." Wiener Klinische Wochenschrift 128, br. 11-12 (2016): 404-413. https://doi.org/10.1007/s00508-016-1005-x

Bedenić, B., et al. (2016) 'Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia', Wiener Klinische Wochenschrift, 128(11-12), str. 404-413. doi: 10.1007/s00508-016-1005-x

Bedenić B, Firis N, Elveđi Gašparović V, Krilanović M, Matanović K, Štimac I, i sur.. Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia. Wiener Klinische Wochenschrift [Internet]. 06.2016. [pristupljeno 15.04.2024.];128(11-12):404-413. doi: 10.1007/s00508-016-1005-x

B. Bedenić, et al., "Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia", Wiener Klinische Wochenschrift, vol. 128, br. 11-12, str. 404-413, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:306351. [Citirano: 15.04.2024.]

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Podaci o radu
Naslov (engleski)Emergence of multidrug-resistant Proteus mirabilis in a long-term care facility in Croatia
AutorBranka Bedenić
AutorNataša Firis
AutorVesna Elveđi-Gašparović
AutorMarija Krilanović
AutorKrešimir Matanović
AutorIva Štimac
AutorJosefa Luxner
AutorJasmina Vraneš
AutorTomislav Meštrović
AutorGernot Zarfel
AutorAndrea Grisold
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: An increased frequency of Proteus mirabilis isolates resistant to expanded-spectrum cephalosporins was observed recently in a long-term care facility in Zagreb (Godan). The aim of this study was the molecular characterization of resistance mechanisms to new cephalosporins in P. mirabilis isolates from this nursing home. ----- METHODS: Thirty-eight isolates collected from 2013-2015 showing reduced susceptibility to ceftazidime were investigated. Antibiotic susceptibilities were determined by broth microdilution method. Inhibitor-based tests were performed to detect extended-spectrum (ESBLs) and AmpC β-lactamases. AmpC β-lactamases were characterized by polymerase chain reaction (PCR) followed by sequencing of bla ampC genes. Quinolone resistance determinants (qnr genes) were characterized by PCR. Genotyping of the isolates was performed by repetitive element sequence (rep)-PCR and pulsed-field gel electrophoresis (PFGE). ----- RESULTS: Presence of an AmpC β-lactamase was confirmed in all isolates by combined-disk test with phenylboronic acid. All isolates were resistant to amoxicillin alone and combined with clavulanate, cefotaxime, ceftriaxone, cefoxitin, and ciprofloxacin; but susceptible to cefepime, imipenem, and meropenem. PCR followed by sequencing using primers targeting bla ampc genes revealed CMY-16 β-lactamase in all but one strain. Bla cmy-16 was carried by a non-conjugative plasmid which did not belong to any known plasmid-based replicon typing (PBRT) group. Rep-PCR identified one large clone consisting of 15 isolates, three pairs or related isolates, one triplet, and four singletons. PFGE confirmed the clonality of the isolates. ----- CONCLUSIONS: This is the first report of multidrug resistant P. mirabilis in a nursing home in Croatia. Cephalosporin resistance was due to plasmid-mediated AmpC β-lactamase CMY-16.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaWiener Klinische Wochenschrift
Brojčani podacivol. 128, br. 11-12, str. 404-413
p-ISSN0043-5325
DOIhttps://doi.org/10.1007/s00508-016-1005-x
URN:NBNurn:nbn:hr:105:306351
Datum objave publikacije2016-06
URL dokumentahttps://doi.org/10.1007/s00508-016-1005-x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:48:53