prikaz prve stranice dokumenta Biomarkers in chronic graft-versus-host disease: quo vadis?
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Biomarkers in chronic graft-versus-host disease: quo vadis?
Bone Marrow Transplantation, 53 (2018), 7; 832-837. https://doi.org/10.1038/s41409-018-0092-x
Wolff, D.; Greinix, H.; Lee, S. J.; Gooley, T.; Paczesny, S.; Pavletic, S.; Hakim, F.; Malard, F.; Jagasia, M.; Lawitschka, A.; Hansen, J. A.; Pulanić, Dražen; Holler, E.; Dickinson, A.; Weissinger, E.; Edinger, M.; Sarantopoulos, S.; Schultz, K. R. Više autora...

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Wolff, D., Greinix, H., Lee, S. J., Gooley, T., Paczesny, S., Pavletic, S. ... Schultz, K. R. (2018). Biomarkers in chronic graft-versus-host disease: quo vadis?. Bone Marrow Transplantation, 53. (7), 832-837. doi: 10.1038/s41409-018-0092-x

Wolff, D., et al. "Biomarkers in chronic graft-versus-host disease: quo vadis?." Bone Marrow Transplantation, vol. 53, br. 7, 2018, str. 832-837. https://doi.org/10.1038/s41409-018-0092-x

Wolff, D., H. Greinix, S. J. Lee, T. Gooley, S. Paczesny, S. Pavletic, F. Hakim, et al. "Biomarkers in chronic graft-versus-host disease: quo vadis?." Bone Marrow Transplantation 53, br. 7 (2018): 832-837. https://doi.org/10.1038/s41409-018-0092-x

Wolff, D., et al. (2018) 'Biomarkers in chronic graft-versus-host disease: quo vadis?', Bone Marrow Transplantation, 53(7), str. 832-837. doi: 10.1038/s41409-018-0092-x

Wolff D, Greinix H, Lee SJ, Gooley T, Paczesny S, Pavletic S, i sur.. Biomarkers in chronic graft-versus-host disease: quo vadis?. Bone Marrow Transplantation [Internet]. 07.2018. [pristupljeno 09.11.2024.];53(7):832-837. doi: 10.1038/s41409-018-0092-x

D. Wolff, et al., "Biomarkers in chronic graft-versus-host disease: quo vadis?", Bone Marrow Transplantation, vol. 53, br. 7, str. 832-837, Srpanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:811224. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:811224
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Naslov (engleski)Biomarkers in chronic graft-versus-host disease: quo vadis?
AutorD. Wolff
AutorH. Greinix
AutorS. J. Lee
AutorT. Gooley
AutorS. Paczesny
AutorS. Pavletic
AutorF. Hakim
AutorF. Malard
AutorM. Jagasia
AutorA. Lawitschka
AutorJ. A. Hansen
AutorDražen Pulanić
AutorE. Holler
AutorA. Dickinson
AutorE. Weissinger
AutorM. Edinger
AutorS. Sarantopoulos
AutorK. R. Schultz
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Biomarkers are increasingly used for diagnosis and treatment of transplant-related complications including the first biomarker-driven interventional trials of acute graft-versus-host disease (GvHD). In contrast, the development of biomarkers of chronic GvHD (cGvHD) has lagged behind due to a broader variety of manifestations, overlap with acute GvHD, a greater variation in time to onset and maximum severity, and lack of sufficient patient numbers within prospective trials. An international workshop organized by a North-American and European consortium was held in Marseille in March 2017 with the goal to discuss strategies for future biomarker development to guide cGvHD therapy. As a result of this meeting, two areas were prioritized: the development of prognostic biomarkers for subsequent onset of moderate/severe cGvHD, and in parallel, the development of qualified clinical-grade assays for biomarker quantification. The most promising prognostic serum biomarkers are CXCL9, ST2, matrix metalloproteinase-3, osteopontin, CXCL10, CXCL11, and CD163. Urine-proteomics and cellular subsets (CD4+ T-cell subsets, NK cell subsets, and CD19+CD21low B cells) represent additional potential prognostic biomarkers of cGvHD. A joint effort is required to verify the results of numerous exploratory trials before any of the potential candidates is ready for validation and subsequent clinical application.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBone Marrow Transplantation
Brojčani podacivol. 53, br. 7, str. 832-837
p-ISSN0268-3369
DOIhttps://doi.org/10.1038/s41409-018-0092-x
URN:NBNurn:nbn:hr:105:811224
Datum objave publikacije2018-07
URL dokumentahttp://doi.org/10.1038/s41409-018-0092-x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:21:12