prikaz prve stranice dokumenta Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
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Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
Journal of Clinical Medicine, 9 (2019), 1; 38. https://doi.org/10.3390/jcm9010038
Mijiritsky, Eitan; Ferroni, Letizia; Gardin, Chiara; Peleg, Oren; Gultekin, Alper; Saglanmak, Alper; Delogu, Lucia Gemma; Mitrečić, Dinko; Piattelli, Adriano; Tatullo, Marco; Zavan, Barbara

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Mijiritsky, E., Ferroni, L., Gardin, C., Peleg, O., Gultekin, A., Saglanmak, A. ... Zavan, B. (2019). Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence. Journal of Clinical Medicine, 9. (1), 38. doi: 10.3390/jcm9010038

Mijiritsky, Eitan, et al. "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence." Journal of Clinical Medicine, vol. 9, br. 1, 2019, str. 38. https://doi.org/10.3390/jcm9010038

Mijiritsky, Eitan, Letizia Ferroni, Chiara Gardin, Oren Peleg, Alper Gultekin, Alper Saglanmak, Lucia Gemma Delogu, et al. "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence." Journal of Clinical Medicine 9, br. 1 (2019): 38. https://doi.org/10.3390/jcm9010038

Mijiritsky, E., et al. (2019) 'Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence', Journal of Clinical Medicine, 9(1), str. 38. doi: 10.3390/jcm9010038

Mijiritsky E, Ferroni L, Gardin C, Peleg O, Gultekin A, Saglanmak A, i sur.. Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence. Journal of Clinical Medicine [Internet]. 23.12.2019. [pristupljeno 24.12.2024.];9(1):38. doi: 10.3390/jcm9010038

E. Mijiritsky, et al., "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence", Journal of Clinical Medicine, vol. 9, br. 1, str. 38, Prosinac 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:513104. [Citirano: 24.12.2024.]

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Naslov (engleski)Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
AutorEitan Mijiritsky
AutorLetizia Ferroni
AutorChiara Gardin
AutorOren Peleg
AutorAlper Gultekin
AutorAlper Saglanmak
AutorLucia Gemma Delogu
AutorDinko Mitrečić
AutorAdriano Piattelli
AutorMarco Tatullo
AutorBarbara Zavan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Analyses of composition, distribution of cellular and extracellular matrix components, and molecular analysis of mitochondria related genes of bone loss in the presence of inflammatory environment in humans was the aim of the present project. As a human model we chose peri-implantitis. Morphological analyses were performed by means classical histological, immunohistochemical, and SEM (scanning electron miscroscopy) test. Gene expression analysis was performed to evaluate epithelium maturation, collagen fiber production, and genes related to mitochondrial activity. It was found that a well-defined keratinocyte epithelium was present on the top of all specimens; a distinct basal lamina was present, as well as desmosomes and autophagic processes related to the maturation of keratinocytes. Under this epithelium, a full inflammatory cell infiltrate was present for about 60% of the represented by plasma cells. Collagen type I fibers were present mainly in the form of fragmented cord tissue without cells. A different distribution of blood vessels was also present from the apical to the most coronal portion of the specimens. High levels of genes related to oxidative stress were present, as well as the activation of genes related to the loss of ability of osteogenic commitment of Mesenchymal stem cells into osteoblasts. Our study suggests that peri-implantitis lesions exhibit a well defined biological organization not only in terms of inflammatory cells but also on vessel and extracellular matrix components even if no difference in the epithelium is evident, and that the presence of reactive oxygen species (ROS) related to the inflammatory environment influences the correct commitment of Mesenchymal stem cells.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 9, br. 1, str. 38
p-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm9010038
URN:NBNurn:nbn:hr:105:513104
Datum objave publikacije2019-12-23
URL dokumentahttp://doi.org/10.3390/jcm9010038
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:41:27