prikaz prve stranice dokumenta Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
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Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
Immunology Letters, 121 (2008), 2; 134-139. https://doi.org/10.1016/j.imlet.2008.10.002
Salopek, Daniela; Grčević, Danka; Katavić, Vedran; Kovačić, Nataša; Lukić, Ivan Krešimir; Marušić, Ana

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Salopek, D., Grčević, D., Katavić, V., Kovačić, N., Lukić, I. K. i Marušić, A. (2008). Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunology Letters, 121. (2), 134-139. doi: 10.1016/j.imlet.2008.10.002

Salopek, Daniela, et al. "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter." Immunology Letters, vol. 121, br. 2, 2008, str. 134-139. https://doi.org/10.1016/j.imlet.2008.10.002

Salopek, Daniela, Danka Grčević, Vedran Katavić, Nataša Kovačić, Ivan Krešimir Lukić i Ana Marušić. "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter." Immunology Letters 121, br. 2 (2008): 134-139. https://doi.org/10.1016/j.imlet.2008.10.002

Salopek, D., et al. (2008) 'Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter', Immunology Letters, 121(2), str. 134-139. doi: 10.1016/j.imlet.2008.10.002

Salopek D, Grčević D, Katavić V, Kovačić N, Lukić IK, Marušić A. Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunology Letters [Internet]. 22.12.2008. [pristupljeno 19.12.2024.];121(2):134-139. doi: 10.1016/j.imlet.2008.10.002

D. Salopek, D. Grčević, V. Katavić, N. Kovačić, I. K. Lukić i A. Marušić, "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter", Immunology Letters, vol. 121, br. 2, str. 134-139, Prosinac 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:080433. [Citirano: 19.12.2024.]

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Naslov (engleski)Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
AutorDaniela Salopek
AutorDanka Grčević
AutorVedran Katavić
AutorNataša Kovačić
AutorIvan Krešimir Lukić
AutorAna Marušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Mice with interleukin (IL)-7 transgene under the control of E(alpha) promoter over-express IL-7 in MHC class II-positive cells and develop specific immune phenotype, marked by an increase in CD45R(+) cells in both the bone marrow and peripheral blood. We show that IL-7 transgenic mice have a bone phenotype characterized by an age-related loss of trabecular bone in both axial and long bones. Osteopenia was the result of increased number of active osteoclasts on the surface of trabecular bone. Furthermore, IL-7 transgenic mice showed increased osteoclastic but unchanged osteoblastic potential of the bone marrow in vitro. IL-7 over-expression also created osteoclastogenic microenvironment within the bone marrow which promoted the commitment of precursors towards the osteoclast lineage. These findings are important for immunological disturbances where IL-7 is involved and where alterations in the immune system are accompanied by changes in bone metabolism, such as multiple myeloma, rheumatoid arthritis and postmenopausal osteoporosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaImmunology Letters
Brojčani podacivol. 121, br. 2, str. 134-139
p-ISSN0165-2478
DOIhttps://doi.org/10.1016/j.imlet.2008.10.002
URN:NBNurn:nbn:hr:105:080433
Datum objave publikacije2008-12-22
URL dokumentahttps://doi.org/10.1016/j.imlet.2008.10.002
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:14:51