prikaz prve stranice dokumenta Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
  Preuzmi
PDF 219.28 KB
Znanstveni rad - Izvorni znanstveni rad
Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
Croatian Medical Journal, 51 (2010), 1; 32-39. https://doi.org/10.3325/cmj.2010.51.32
Polašek, Ozren; Jerončić, Iris; Mulić, Rosanda; Klišmanić, Zorana; Pehlić, Marina; Zemunik, Tatijana; Kolčić, Ivana

Citirajte ovaj rad

Polašek, O., Jerončić, I., Mulić, R., Klišmanić, Z., Pehlić, M., Zemunik, T. i Kolčić, I. (2010). Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Croatian Medical Journal, 51. (1), 32-39. doi: 10.3325/cmj.2010.51.32

Polašek, Ozren, et al. "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series." Croatian Medical Journal, vol. 51, br. 1, 2010, str. 32-39. https://doi.org/10.3325/cmj.2010.51.32

Polašek, Ozren, Iris Jerončić, Rosanda Mulić, Zorana Klišmanić, Marina Pehlić, Tatijana Zemunik i Ivana Kolčić. "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series." Croatian Medical Journal 51, br. 1 (2010): 32-39. https://doi.org/10.3325/cmj.2010.51.32

Polašek, O., et al. (2010) 'Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series', Croatian Medical Journal, 51(1), str. 32-39. doi: 10.3325/cmj.2010.51.32

Polašek O, Jerončić I, Mulić R, Klišmanić Z, Pehlić M, Zemunik T, i sur.. Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Croatian Medical Journal [Internet]. 15.02.2010. [pristupljeno 19.12.2024.];51(1):32-39. doi: 10.3325/cmj.2010.51.32

O. Polašek, et al., "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series", Croatian Medical Journal, vol. 51, br. 1, str. 32-39, Veljača 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:188020. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:188020
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
AutorOzren Polašek
AutorIris Jerončić
AutorRosanda Mulić
AutorZorana Klišmanić
AutorMarina Pehlić
AutorTatijana Zemunik
AutorIvana Kolčić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim. To investigate whether intra-personal variation in serum uric acid concentration is influenced by genes that were described to be associated with serum uric acid levels in cross-sectional studies. ----- Methods. The study included 92 participants from the isolated community of the Croatian island of Vis. For each participant, two uric acid concentration measurements were available, one from 2002 and one from 2003. Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. ----- Results. Thirteen participants (14%) had uric acid concentration change greater than 130 mumol/L. Greater variability of uric acid concentration was recorded in women (coefficient of variation 49% vs 12% in men). Two SNPs belonging to SLC17A3 gene (rs9393672 and rs942379) yielded significant association with serum uric acid concentration changes in women. These two single-nucleotide polymorphisms (SNP) explained 0.2%-1.3% of variance for 2002 or 2003 uric acid measurement and 1.1%-1.8% of variance for the average value of these two measurements. ----- Conclusions. Repeated measurements offer a possibility to enrich the percent of explained variance and contribute to the understanding of the "missing heritability" concept. Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 51, br. 1, str. 32-39
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2010.51.32
URN:NBNurn:nbn:hr:105:188020
Datum objave publikacije2010-02-15
URL dokumentahttp://www.cmj.hr/2010/51/1/20162743.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:31:01