prikaz prve stranice dokumenta Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
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Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
Journal of Oral Pathology & Medicine, 37 (2008), 5; 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x
Malčić, Ana; Jukić, Silvana; Anić, Ivica; Pavelić, Božidar; Kapitanović, Sanja; Krušlin, Božo; Pavelić, Krešimir

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Malčić, A., Jukić, S., Anić, I., Pavelić, B., Kapitanović, S., Krušlin, B. i Pavelić, K. (2008). Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst. Journal of Oral Pathology & Medicine, 37. (5), 294-301. doi: 10.1111/j.1600-0714.2007.00622.x

Malčić, Ana, et al. "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst." Journal of Oral Pathology & Medicine, vol. 37, br. 5, 2008, str. 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x

Malčić, Ana, Silvana Jukić, Ivica Anić, Božidar Pavelić, Sanja Kapitanović, Božo Krušlin i Krešimir Pavelić. "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst." Journal of Oral Pathology & Medicine 37, br. 5 (2008): 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x

Malčić, A., et al. (2008) 'Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst', Journal of Oral Pathology & Medicine, 37(5), str. 294-301. doi: 10.1111/j.1600-0714.2007.00622.x

Malčić A, Jukić S, Anić I, Pavelić B, Kapitanović S, Krušlin B, i sur.. Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst. Journal of Oral Pathology & Medicine [Internet]. 05.2008. [pristupljeno 02.05.2024.];37(5):294-301. doi: 10.1111/j.1600-0714.2007.00622.x

A. Malčić, et al., "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst", Journal of Oral Pathology & Medicine, vol. 37, br. 5, str. 294-301, Svibanj 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:443461. [Citirano: 02.05.2024.]

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Naslov (engleski)Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
AutorAna Malčić
AutorSilvana Jukić
AutorIvica Anić
AutorBožidar Pavelić
AutorSanja Kapitanović
AutorBožo Krušlin
AutorKrešimir Pavelić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) and radicular cysts (RC). ----- METHODS: The methods used were immunohistochemistry and molecular genetic methods including loss of heterozygosity (LOH) and gene sequencing. ----- RESULTS: FHIT protein expression was different among groups. Aberrant expression was the highest in KOT, then in RC and DC. p53 protein expression was different among groups. LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT and p53 respectively. Mutation of p53 gene at codon 237 was observed in only two specimens (one KOT and one DC). Of the six frozen specimens, three exhibited FHIT gene LOH (two RC and one KOT). KOT showed loss of exons 6-7 at FHIT locus and mutation at codon 237 at p53 locus, but this could be a chance result. ----- CONCLUSION: Aberrations of FHIT and p53 genes/proteins could be considered markers responsible for the development of odontogenic lesions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Oral Pathology & Medicine
Brojčani podacivol. 37, br. 5, str. 294-301
p-ISSN0904-2512
DOIhttps://doi.org/10.1111/j.1600-0714.2007.00622.x
URN:NBNurn:nbn:hr:105:443461
Datum objave publikacije2008-05
URL dokumentahttps://doi.org/10.1111/j.1600-0714.2007.00622.x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:35:01