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The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status
Diagnostics, 13 (2023), 18; 2960. https://doi.org/10.3390/diagnostics13182960
Stojić, Josip; Kukla, Michał; Grgurević, Ivica

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Stojić, J., Kukla, M. i Grgurević, I. (2023). The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status. Diagnostics, 13. (18). doi: 10.3390/diagnostics13182960

Stojić, Josip, et al. "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status." Diagnostics, vol. 13, br. 18, 2023. https://doi.org/10.3390/diagnostics13182960

Stojić, Josip, Michał Kukla i Ivica Grgurević. "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status." Diagnostics 13, br. 18 (2023). https://doi.org/10.3390/diagnostics13182960

Stojić, J., Kukla, M. i Grgurević, I. (2023) 'The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status', Diagnostics, 13(18). doi: 10.3390/diagnostics13182960

Stojić J, Kukla M, Grgurević I. The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status. Diagnostics [Internet]. 15.09.2023. [pristupljeno 20.12.2024.];13(18). doi: 10.3390/diagnostics13182960

J. Stojić, M. Kukla i I. Grgurević, "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status", Diagnostics, vol. 13, br. 18, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:495792. [Citirano: 20.12.2024.]

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Podaci o radu
Naslov (engleski)The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status
AutorJosip Stojić
AutorMichał Kukla
AutorIvica Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Chronic liver disease (CLD) is a significant global health burden, leading to millions of deaths annually. The gut–liver axis plays a pivotal role in this context, allowing the transport of gut-derived products directly to the liver, as well as biological compounds from the liver to the intestine. The gut microbiota plays a significant role in maintaining the health of the digestive system. A change in gut microbiome composition as seen in dysbiosis is associated with immune dysregulation, altered energy and gut hormone regulation, and increased intestinal permeability, contributing to inflammatory mechanisms and damage to the liver, irrespective of the underlying etiology of CLD. The aim of this review is to present the current knowledge about the composition of the intestinal microbiome in healthy individuals and those with CLD, including the factors that affect this composition, the impact of the altered microbiome on the liver, and the mechanisms by which it occurs. Furthermore, this review analyzes the effects of gut microbiome modulation on the course of CLD, by using pharmacotherapy, nutrition, fecal microbiota transplantation, supplements, and probiotics. This review opens avenues for the translation of knowledge about gut–liver interplay into clinical practice as an additional tool to fight CLD and its complications.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostics
Brojčani podacivol. 13, br. 18, 2960
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics13182960
URN:NBNurn:nbn:hr:105:495792
Datum objave publikacije2023-09-15
URL dokumentahttps://www.mdpi.com/2075-4418/13/18/2960
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-21 08:54:16