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Ekstrahepatalne manifestacije kroničnog hepatitisa C
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Filip Grabant Virusom hepatitisa C (HCV) danas je zaraženo 71 milijun ljudi ili oko 1% svjetske populacije, dok od posljedica zaraze godišnje umre 399 tisuća ljudi. U 55% do 85% inficiranih osoba dolazi do razvoja kroničnog hepatitisa C (CHC), sistemne bolesti koja se može komplicirati jetrenim (ciroza jetre i hepatocelularni karcinom) i ekstrahepatalnim manifestacijama (EHM). Prvi i jedini znak CHC mogu biti EHM, a javljaju se u čak do 74% CHC oboljelih. Ekstrahepatalne manifestacije mogu se...
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Ekstrahepatalne manifestacije virusnih hepatitisa
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Adna Omerčahić Povijest su obilježile brojne epidemije žutice, prvi puta zabilježene u Kini prije 5000 godina. Razvojem tehnologije, od sredine dvadesetog stoljeća do danas, uspješno su identificirani i izolirani njihovi uzročnici te svrstani u skupine od A do E. Iako se virusni hepatitisi tradicionalno vežu za širok spektar jetrenih bolesti (od akutnog, fulminantnog i kroničnog hepatitisa do ciroze jetre i hepatocelularnog karcinoma), današnja saznanja sve više ukazuju na povezanost s razvojem...
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Ekvivalent: Alloiococcus otitidis - uzrok nespecifičnog akutnog sinusitisa: prikaz slučaja i pregled literature
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Tanja Grubić Kezele Although most sinus infections are viral, potential bacterial pathogens such as Streptococcus pneumoniae, Haemophilus influenza and Moraxella catarrhalis can migrate during a viral respiratory infection from the nasopharynx into the sinus cavity causing sinusitis. Alloiococcus otitidis is a commensal of the external auditory canal and is considered one of the potential middle ear pathogens. Unlike most otopathogens, A. otitidis is rarely found in the nasopharynx of healthy individuals. This...
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Ekvivalent: Globulin koji veže spolne hormone (SHBG) kao marker u kliničkim poremećajima
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Karlo Toljan Sex hormone binding globulin (SHBG) is an important protein, not only for transporting sex steroids which is its primary role, but with the discovery of a specific receptor that binds SHBG, a novel approach regarding classic ‘freehormone hypothesis’ should be implemented. Research in SHBG gene and it expression has been done, as well as cellular signaling that controls it. It provides significant knowledge of the impact of certain well –defined cellular level signaling pathways and how...
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Ekvivalent: Granulomatoza s poliangiitisom i lokaliziranim zahvaćanjem gornjega dišnoga sustava ‒ prikaz bolesnice
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Ivan Marković Granulomatoza s poliangiitisom (Wegenerova granulomatoza) ubraja se u vaskulitise malih krvnih žila povezane s antineutrofilnim citoplazmatskim protutijelima. Najčešće su zahvaćeni gornji i donji dišni sustav te bubrezi. Obilježjan bolesti uključuju granulomatoznu upalu dišnog sustava i nekrotizirajući vaskulitis malih do srednje velikih krvnih žila. U većine je bolesnika pri postavljanju dijagnoze zahvaćeno više organskih sustava te mogu biti prisutni i opći simptomi, dok je...
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Ekvivalent: Non-Hodgkinov limfom frontalnog sinusa – prikaz slučaja i pregled literature
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Sandra Doko Primary frontal sinus Non-Hodgkin's lymphoma (NHL) is an extremely rare condition with 20 cases published in the existing literature to date. We describe a 64-year-old patient who presented with right orbital pain, severe headache and diplopia. He was initially diagnosed with acute exacerbation of chronic rhinosinusitis and responded well to antibiotic treatment, but his symptoms returned. The diagnosis of frontal sinus NHL was made only after functional endoscopic frontal sinus surgery was...
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Ekvivalent: Poslijeoperacijski kognitivni poremećaji nakon kardiokirurškog zahvata
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Sandro Glumac The growing number of publications concerning postoperative cognitive decline (POCD) after cardiac surgery is indicative of the health-related and economic-related importance of this intriguing issue. Significantly, the reported POCD incidence over the years has remained steady due to various unresolved challenges regarding the examination of this multidisciplinary topic. In particular, a universally accepted POCD definition has not been established, and the pathogenesis is still vaguely...
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